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HHS Guidance Portal

The Guidance Portal is a public website that shows current guidance documents from the U.S. Department of Health and Human Services (HHS) and its Divisions.

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HHS Guidance Documents
Title OpDiv/StaffDiv Guidance Status Issue Date
Quantitative Systems Pharmacology (QSP)-Based Dose Selection for Minimum Anticipated Biological Effect Level (MABEL) in First-in-Human (FIH) Trials  Food and Drug Administration (FDA) Proposed
July Quarterly Update for 2026 Durable Medical Equipment, Prosthetics, Orthotics and Supplies (DMEPOS) Fee Schedule  Centers for Medicare & Medicaid Services (CMS) Final
Submitting Clinical Trial Datasets to Evaluate the Impact of Immunogenicity on the Pharmacokinetics of a Drug  Food and Drug Administration (FDA) Final
MN CY 2027 HPMS release memo G.pdf  Centers for Medicare & Medicaid Services (CMS) Final
October 2026 (2027 File) Update of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM)  Centers for Medicare & Medicaid Services (CMS) Final
VA CY 2027 HPMS release memo G.pdf  Centers for Medicare & Medicaid Services (CMS) Final
WI CY 2027 HPMS release memo G.pdf  Centers for Medicare & Medicaid Services (CMS) Final
Update to Several Sections of the Internet-Only Manual (IOM) Publication (Pub.) 100-04, Medicare Claims Processing Manual, Chapter 23 - Fee Schedule Administration and Coding Requirements  Centers for Medicare & Medicaid Services (CMS) Final
IL CY 2027 AIP D SNP HPMS release memo G.pdf  Centers for Medicare & Medicaid Services (CMS) Final
Indiana CY 2027 AIP D SNP HPMS release memo G.pdf  Centers for Medicare & Medicaid Services (CMS) Final
This Guidance Portal contains 5524 documents.