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HHS Guidance Portal

The Guidance Portal is a public website that shows current guidance documents from the U.S. Department of Health and Human Services (HHS) and its Divisions.

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HHS Guidance Documents
Title OpDiv/StaffDiv Guidance Status Issue Date
E6(R3) Good Clinical Practice: Annex 2  Food and Drug Administration (FDA) Proposed
M15 General Principles for Model-Informed Drug Development  Food and Drug Administration (FDA) Proposed
Protocol Deviations for Clinical Investigations of Drugs, Biological Products, and Devices  Food and Drug Administration (FDA) Proposed
Basic Requirements for Conducting Ex Parte Renewals of Medicaid and CHIP Eligibility  Centers for Medicare & Medicaid Services (CMS) Final
2025 SSI, Spousal Impoverishment, and Medicare Savings Program Resource Standards  Centers for Medicare & Medicaid Services (CMS) Final
Use of Unwinding-Related Strategies to Support Long-Term Improvements to State Medicaid Eligibility and Enrollment Processes  Centers for Medicare & Medicaid Services (CMS) Final
State Medicaid Director Letter: Permanent Extension of Mandatory Medicaid State Plan Coverage of MAT/MOUD  Centers for Medicare & Medicaid Services (CMS) Final
Financial Eligibility Verification Requirements and Flexibilities  Centers for Medicare & Medicaid Services (CMS) Final
Protecting Medicaid Beneficiaries Against Impermissible Fraud and Abuse Sanctions (SMD 24-005) [RESCINDED ON MAY 1, 2025]  Centers for Medicare & Medicaid Services (CMS) Final
Coverage of Services and Supports to Address Health-Related Social Needs in Medicaid and CHIP  Centers for Medicare & Medicaid Services (CMS) Final
This Guidance Portal contains 4735 documents.